Many years ago, in imperial Japan, advances in a mysterious science called "meta-topology" have led to the unexpected prosperity of the Heian era. A special university was founded by the scientists, where researches in bio- and nano-technology were conducted. Since women dominated society during that time, they were the ones imbued with the powers of meta-topology. A series of conflicts between reactionary governments and the "meta-women", as they began calling themselves, continued thousands years into the future. Led by Mayumi Tanaka, president of the astronomy department, a group of young women tries to protect their existence using their remarkable powers.