Condemned to an eternal vegetative state, the very sexy Druuna is waiting for someone to free her from her sick, claustrophobic and dilapidated world, inhabited by people suffering from a terrible virus that transforms them into bloodthirsty beasts. A symbiotic computer directly linked to Druuna's brain is the only thing that can help you to capture and to relive the situations that have reduced her to a state of "cold sleep". You must try to avoid the unscrupulous individuals that live in her mind and face the traps hidden along this uncertain road leading finally to salvation.