The plot of the game closely follows that of House of the Dead 2.[2] The story begins on February 26, 2000, when several AMS agents have been dispatched to investigate a zombie outbreak in Venice, Italy. The player can control two characters, James and Gary, who are sent to find the original game's "G" and then tasked with restoring order.Responsibility for the outbreaks is soon traced to "Goldman," a banking tycoon and scientist who attempts to end human control of the earth. Much of the game revolves around destroying Goldman's creations, concluding with the final boss of "the Emperor." One of three possible humorous ending sequences occurs, depending on the answers given to the questions asked to defeat the Emperor.