Set in 2096, the story of Front Mission 4 takes place in Venezuela and Europe. Since the revelations of the true causes behind the 2nd Huffman Conflict in 2092, the world grew wary of the Republic of Zaftra. Zaftra began losing foreign investments and many businesses withdrew from the union, resulting in major economic losses. Superpowers such as the United States of the New Continent (USN) refused offers from the union to import their natural resources, the major economic driver of their economy. With a failing economy and growing distrust from the world community, the Republic of Zaftra disbanded the Peace Mediation Organization (PMO) in 2094. Meanwhile, the discovery of natural resources in Poland led the European Community (EC) to stop importing raw materials from Zaftra. Consequently, Zaftran citizens began migrating to other countries in search for work. In 2096, the Republic of Zaftra returned to the spotlight after a mysterious blitzkrieg of EC military bases leaves Europe in an imminent resource crisis. Elsewhere in the world, Venezuela suddenly declares independence from the USN.