When assaulted by a gang of vicious thugs, a shady drifter named Gene gets his right arm cut off. When he comes to, he finds himself with a young girl at his side, and his right arm reattached. But this is no longer an ordinary arm: it's been replaced with the legendary 'God Hand', and now that he's got it, Gene's on the hunt by every demon in the county, as they all want their hands on his. And with four powerful figures planning the demise of the world, things are probably gonna get ugly.