The player takes the role of Prince Pixel of the Canvas Kingdom. Long ago, the kingdom was besieged by an evil Devil. This Devil was sealed away by a few brave knights bestowed with the power of Graffiti (called Graffiticians). Pixel happens upon the Devil's seal whilst avoiding his studies and takes the graffiti wand, breaking the seal. After an attempt by the seal's guardian, Pastel, to teach Pixel to use the wand results in the Devil's release, Pastel has Pixel face the Devil and restore the kingdom. Along the way, he meets Tablet, the Devil's son, who helps Pixel and challenges him throughout his adventures. He makes his way through the first few worlds, beating their bosses and acquiring their keys. En route to Palette, Tablet's sister, Pastel is kidnapped by Palette's agent. Pixel proceeds to fight his way to Palette's palace, reaffirming the friendship Pixel has with Pastel. Pixel then faces off with Palette, defeating her. However, Tablet is seemingly killed when he takes an attack meant for Pixel. Determined to stop the Devil, Pixel fights through the Devil's palace and beats the Devil, leaving him near defeat. However, Tablet steals Pixel's wand and defeats his father instead before declaring himself the new Devil. Pastel gives Pixel a spare wand (many others of which she keeps inside her). Pixel defeats Tablet and creates a new body for him. Pixel then stops Pastel from re-sealing the Devil, which would also cause Pastel to be sealed in with him. The Devil escapes once more, albeit now severely weakened. Pixel agrees to let the Devil recuperate if he restores the kingdom as best he can. The ending cinematic shows Palette rampaging through the town before being battled offscreen by Pixel and Tablet.