You are the rapper 50 Cent in the streets of New York. You receive a urgent page for one of your old cell mates K-Dog, which leads you into a ambush where 50 Cent gets shot nine times and is left to die. After 50 survives you are back out in the streets sneaking for revenge. 50 gets caught up in a underground world working along side with G-Unit soldiers Lloyd Banks, Young Buck, and Tony Yayo. You go through the game dealing with shady deals and people while taking on the most dangerous crime organization in all of New York City. 50 puts in work to uncover the truth behind the international conspiracy that is being fueled by the streets.